
Research into the causes of aging, and strategies to delay that process, have gained much ground and attention in recent years. This authoritative volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among the specific topics covered are calorie restriction, oxidative stress, sirtuins, telomeres, and stem cells. It also contains chapters on specific model organisms, including Drosophila, mice, and yeast, which discuss how each species has contributed to our understanding of the aging process. Finally, this book includes discussions about the potential for developing new drugs and therapeutics to regulate aging and ameliorate aging-related diseases, such as Alzheimer's disease and cancer.
Table of Contents
| Preface/Front Matter |
| Lenny Guarente, Linda Partridge, Doug Wallace |
| Excerpt PDF (i-viii) |
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| 1 The Human Mitochondrion and Pathophysiology of Aging and Age-related Diseases |
| Douglas C. Wallace |
| Excerpt PDF (1-38) |
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| 2 Sirtuins: A Universal Link between NAD, Metabolism, and Aging |
| Shin-ichiro Imai, Leonard P. Guarente |
| Excerpt PDF (39-72) |
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| 3 Calorie Restriction in Lower Organisms |
| Stephen L. Helfand, Johannes H. Bauer, Jason G. Wood |
| Excerpt PDF (73-93) |
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| 4 Evolutionary Theory in Aging Research |
| Steven N. Austad, Thomas B.L. Kirkwood |
| Excerpt PDF (95-111) |
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| 5 An Overview of the Biology of Aging: A Human Perspective |
| George M. Martin, Caleb E. Finch |
| Excerpt PDF (113-126) |
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| 6 p53, Cancer, and Longevity |
| Lawrence A. Donehower, Arnold J. Levine |
| Excerpt PDF (127-152) |
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| 7 Aging Processes in Caenorhabditis elegans |
| Heidi A. Tissenbaum, Thomas E. Johnson |
| Excerpt PDF (153-183) |
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| 8 Cellular Senescence: A Link between Tumor Suppression and Organismal Aging? |
| John M. Sedivy, Ursula M. Munoz-Najar, Jessie C. Jeyapalan, Judith Campisi |
| Excerpt PDF (185-214) |
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| 9 Genome-wide Views of Aging Gene Networks |
| Stuart K. Kim |
| Excerpt PDF (215-235) |
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| 10 Aging in Mammalian Stem Cells and Other Self-renewing Compartments |
| Derrick J. Rossi, Norman E. Sharpless |
| Excerpt PDF (237-265) |
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| 11 Yeast, a Feast: The Fruit Fly Drosophila as a Model Organism for Research into Aging |
| Linda Partridge, John Tower |
| Excerpt PDF (267-308) |
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| 12 DNA Repair and Aging |
| Vilhelm A. Bohr, David M. Wilson, Iii, Nadja C. De Souza-pinto, Ingrid van der Pluijm, J.H. Hoeijmakers |
| Excerpt PDF (309-346) |
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| 13 Extended Life Span in Mice with Reduction in the GH/IGF-1 Axis |
| John J. Kopchick, Andrzej Bartke, Darlene E. Berryman |
| Excerpt PDF (347-369) |
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| 14 Alzheimer’s Disease: Genetics, Pathogenesis, Models, and Experimental Therapeutics |
| Philip C. Wong, Donald L. Price, Lars Bertram, Ronald E. Tanzi |
| Excerpt PDF (371-407) |
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| 15 How Does Caloric Restriction Increase the Longevity of Mammals? |
| Richard Weindruch, Ricki J. Colman, Viviana Pérez, Arlan G. Richardson |
| Excerpt PDF (409-425) |
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| 16 Determination of Aging Rate by Coordinated Resistance to Multiple Forms of Stress |
| Gordon J. Lithgow, Richard A. Miller |
| Excerpt PDF (427-481) |
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| 17 Molecular Mechanisms of Aging: Insights from Budding Yeast |
| Su-Ju Lin, David Sinclair |
| Excerpt PDF (483-516) |
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| 18 Genetics of Exceptional Longevity |
| Thomas T. Perls, Paola Sebastiani |
| Excerpt PDF (517-544) |
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| 19 Mammalian Metabolism in Aging |
| Pere Puigserver, C. Ronald Kahn |
| Excerpt PDF (545-574) |
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| 20 Telomeres and Telomerase in Aging and Cancer |
| Jerry W. Shay, Woodring E. Wright |
| Excerpt PDF (575-597) |
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| Index |
| Excerpt PDF (599-610) |
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