Molecular Biology of Aging (2008, Volume 51)

Cover Page

Research into the causes of aging, and strategies to delay that process, have gained much ground and attention in recent years. This authoritative volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among the specific topics covered are calorie restriction, oxidative stress, sirtuins, telomeres, and stem cells. It also contains chapters on specific model organisms, including Drosophila, mice, and yeast, which discuss how each species has contributed to our understanding of the aging process. Finally, this book includes discussions about the potential for developing new drugs and therapeutics to regulate aging and ameliorate aging-related diseases, such as Alzheimer's disease and cancer.

Table of Contents

Preface/Front Matter
Lenny Guarente, Linda Partridge, Doug Wallace
Excerpt       PDF     (i-viii)
1 The Human Mitochondrion and Pathophysiology of Aging and Age-related Diseases
Douglas C. Wallace
Excerpt       PDF     (1-38)
2 Sirtuins: A Universal Link between NAD, Metabolism, and Aging
Shin-ichiro Imai, Leonard P. Guarente
Excerpt       PDF     (39-72)
3 Calorie Restriction in Lower Organisms
Stephen L. Helfand, Johannes H. Bauer, Jason G. Wood
Excerpt       PDF     (73-93)
4 Evolutionary Theory in Aging Research
Steven N. Austad, Thomas B.L. Kirkwood
Excerpt       PDF     (95-111)
5 An Overview of the Biology of Aging: A Human Perspective
George M. Martin, Caleb E. Finch
Excerpt       PDF     (113-126)
6 p53, Cancer, and Longevity
Lawrence A. Donehower, Arnold J. Levine
Excerpt       PDF     (127-152)
7 Aging Processes in Caenorhabditis elegans
Heidi A. Tissenbaum, Thomas E. Johnson
Excerpt       PDF     (153-183)
8 Cellular Senescence: A Link between Tumor Suppression and Organismal Aging?
John M. Sedivy, Ursula M. Munoz-Najar, Jessie C. Jeyapalan, Judith Campisi
Excerpt       PDF     (185-214)
9 Genome-wide Views of Aging Gene Networks
Stuart K. Kim
Excerpt       PDF     (215-235)
10 Aging in Mammalian Stem Cells and Other Self-renewing Compartments
Derrick J. Rossi, Norman E. Sharpless
Excerpt       PDF     (237-265)
11 Yeast, a Feast: The Fruit Fly Drosophila as a Model Organism for Research into Aging
Linda Partridge, John Tower
Excerpt       PDF     (267-308)
12 DNA Repair and Aging
Vilhelm A. Bohr, David M. Wilson, Iii, Nadja C. De Souza-pinto, Ingrid van der Pluijm, J.H. Hoeijmakers
Excerpt       PDF     (309-346)
13 Extended Life Span in Mice with Reduction in the GH/IGF-1 Axis
John J. Kopchick, Andrzej Bartke, Darlene E. Berryman
Excerpt       PDF     (347-369)
14 Alzheimer’s Disease: Genetics, Pathogenesis, Models, and Experimental Therapeutics
Philip C. Wong, Donald L. Price, Lars Bertram, Ronald E. Tanzi
Excerpt       PDF     (371-407)
15 How Does Caloric Restriction Increase the Longevity of Mammals?
Richard Weindruch, Ricki J. Colman, Viviana Pérez, Arlan G. Richardson
Excerpt       PDF     (409-425)
16 Determination of Aging Rate by Coordinated Resistance to Multiple Forms of Stress
Gordon J. Lithgow, Richard A. Miller
Excerpt       PDF     (427-481)
17 Molecular Mechanisms of Aging: Insights from Budding Yeast
Su-Ju Lin, David Sinclair
Excerpt       PDF     (483-516)
18 Genetics of Exceptional Longevity
Thomas T. Perls, Paola Sebastiani
Excerpt       PDF     (517-544)
19 Mammalian Metabolism in Aging
Pere Puigserver, C. Ronald Kahn
Excerpt       PDF     (545-574)
20 Telomeres and Telomerase in Aging and Cancer
Jerry W. Shay, Woodring E. Wright
Excerpt       PDF     (575-597)
Excerpt       PDF     (599-610)