Molecular Biology of Aging

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Research into the causes of aging, and strategies to delay that process, have gained much ground and attention in recent years. This authoritative volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among the specific topics covered are calorie restriction, oxidative stress, sirtuins, telomeres, and stem cells. It also contains chapters on specific model organisms, including Drosophila, mice, and yeast, which discuss how each species has contributed to our understanding of the aging process. Finally, this book includes discussions about the potential for developing new drugs and therapeutics to regulate aging and ameliorate aging-related diseases, such as Alzheimer's disease and cancer.

Table of Contents

Articles

Lenny Guarente, Linda Partridge, Doug Wallace
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i-viii
Douglas C. Wallace
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1-38
Shin-ichiro Imai, Leonard P. Guarente
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39-72
Stephen L. Helfand, Johannes H. Bauer, Jason G. Wood
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73-93
Steven N. Austad, Thomas B.L. Kirkwood
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95-111
George M. Martin, Caleb E. Finch
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113-126
Lawrence A. Donehower, Arnold J. Levine
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127-152
Heidi A. Tissenbaum, Thomas E. Johnson
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153-183
John M. Sedivy, Ursula M. Munoz-Najar, Jessie C. Jeyapalan, Judith Campisi
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185-214
Stuart K. Kim
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215-235
Derrick J. Rossi, Norman E. Sharpless
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237-265
Linda Partridge, John Tower
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267-308
Vilhelm A. Bohr, David M. Wilson, Iii, Nadja C. De Souza-pinto, Ingrid van der Pluijm, J.H. Hoeijmakers
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309-346
John J. Kopchick, Andrzej Bartke, Darlene E. Berryman
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347-369
Philip C. Wong, Donald L. Price, Lars Bertram, Ronald E. Tanzi
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371-407
Richard Weindruch, Ricki J. Colman, Viviana Pérez, Arlan G. Richardson
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409-425
Gordon J. Lithgow, Richard A. Miller
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427-481
Su-Ju Lin, David Sinclair
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483-516
Thomas T. Perls, Paola Sebastiani
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517-544
Pere Puigserver, C. Ronald Kahn
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545-574
Jerry W. Shay, Woodring E. Wright
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575-597
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599-610