
Hundreds of genomes have been completely sequenced in the past decade, significantly advancing our understanding of genome structure and function. Genomes comprises a collection of review articles reprinted from the 10th Anniversary Issue of the journal Genome Research that captures the status of genomic research in a selection of model species-from microbes to human.
Written by renowned leaders in the field of genomics, each chapter focuses on what has been learned from the genomes of a given kingdom, group, or species and offers a unique perspective on the history, the current status, and the future of genomic research efforts. A variety of topics are addressed, including gene regulatory networks in the fruit fly and the sea squirt, fungal genome evolution, mouse and rat mutagenesis, and the future of crop plant genomics. How livestock genomics informs human medicine, the importance of the dog genome in studying human disease, and the search for "humanness" through human and chimp genome comparisons are also presented in thoughtful discussions. In addition, updates on emerging technologies in DNA sequencing and in gene prediction, as well as direction to relevant public resources, are given.
This book serves as a valuable reference and teaching tool for established scientists in the genomics field and as a comprehensive overview for those with more general interests in biology.
Table of Contents
| Preface/Front Matter |
| Hillary E. Sussman, Maria A. Smit |
| Excerpt PDF (i-x) |
|   |
| 1 Insights on Biology and Evolution from Microbial Genome Sequencing |
| Claire M. Fraser-Liggett |
| Excerpt PDF (1-17) |
|   |
| 2 Changing Perspectives in Yeast Research Nearly a Decade after the Genome Sequence |
| Kara Dolinski, David Botstein |
| Excerpt PDF (19-39) |
|   |
| 3 Genomics of the Fungal Kingdom: Insights into Eukaryotic Biology |
| James E. Galagan, Matthew R. Henn, Li-Jun Ma, Christina A. Cuomo, Bruce Birren |
| Excerpt PDF (41-69) |
|   |
| 4 The Arabidopsis Genome: A Foundation for Plant Research |
| Michael Bevan, Sean Walsh |
| Excerpt PDF (71-96) |
|   |
| 5 Grains of Knowledge: Genomics of Model Cereals |
| Andrew H. Paterson, Michael Freeling, Takuji Sasaki |
| Excerpt PDF (97-116) |
|   |
| 6 Genomics in Caenorhabditis elegans: So Many Genes, Such a Little Worm |
| LaDeana W. Hillier, Alan Coulson, John I. Murray, Zhirong Bao, John E. Sulston, Robert H. Waterston |
| Excerpt PDF (117-141) |
|   |
| 7 Drosophila melanogaster: A Case Study of a Model Genomic Sequence and Its Consequences |
| Michael Ashburner, Casey M. Bergman |
| Excerpt PDF (143-158) |
|   |
| 8 Unraveling Genomic Regulatory Networks in the Simple Chordate, Ciona intestinalis |
| Weiyang Shi, Michael Levine, Brad Davidson |
| Excerpt PDF (159-175) |
|   |
| 9 Fish Genomics and Biology |
| Hugues Roest Crollius, Jean Weissenbach |
| Excerpt PDF (177-197) |
|   |
| 10 Xenomics |
| Enrique Amaya |
| Excerpt PDF (199-220) |
|   |
| 11 Chicken Genome: Current Status and Future Opportunities |
| David W. Burt |
| Excerpt PDF (221-236) |
|   |
| 12 Advances in Livestock Genomics: Opening the Barn Door |
| James E. Womack |
| Excerpt PDF (237-254) |
|   |
| 13 The Canine Genome |
| Elaine A. Ostrander, Robert K. Wayne |
| Excerpt PDF (255-279) |
|   |
| 14 Impact of Genomics on Research in the Rat |
| Jozef Lazar, Carol Moreno, Howard J. Jacob, Anne E. Kwitek |
| Excerpt PDF (281-311) |
|   |
| 15 The Mouse Genome |
| Jean Louis Guénet |
| Excerpt PDF (313-343) |
|   |
| 16 Genomics of the Future: Identification of Quantitative Trait Loci in the Mouse |
| Lorraine Flaherty, Bruce Herron, Derek Symula |
| Excerpt PDF (345-356) |
|   |
| 17 Comparing the Human and Chimpanzee Genomes: Searching for Needles in a Haystack |
| Ajit Varki, Tasha K. Altheide |
| Excerpt PDF (357-393) |
|   |
| 18 Structure and Function of the Human Genome |
| Peter F.R. Little |
| Excerpt PDF (395-412) |
|   |
| 19 Emerging Technologies in DNA Sequencing |
| Michael L. Metzker |
| Excerpt PDF (413-438) |
|   |
| 20 Genome Annotation Past, Present, and Future: How to Define an Open Reading Frame at Each Locus |
| Michael R. Brent |
| Excerpt PDF (439-463) |
|   |
| Index |
| Excerpt PDF (465-475) |
|   |