Research into the causes of aging, and strategies to delay that process, have gained much ground and attention in recent years. This authoritative volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among the specific topics covered are calorie restriction, oxidative stress, sirtuins, telomeres, and stem cells. It also contains chapters on specific model organisms, including Drosophila, mice, and yeast, which discuss how each species has contributed to our understanding of the aging process. Finally, this book includes discussions about the potential for developing new drugs and therapeutics to regulate aging and ameliorate aging-related diseases, such as Alzheimer's disease and cancer.
Table of Contents
Articles
Lenny Guarente, Linda Partridge, Doug Wallace
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i-viii
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Douglas C. Wallace
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1-38
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Shin-ichiro Imai, Leonard P. Guarente
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39-72
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Stephen L. Helfand, Johannes H. Bauer, Jason G. Wood
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73-93
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Steven N. Austad, Thomas B.L. Kirkwood
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95-111
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George M. Martin, Caleb E. Finch
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113-126
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Lawrence A. Donehower, Arnold J. Levine
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127-152
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Heidi A. Tissenbaum, Thomas E. Johnson
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153-183
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John M. Sedivy, Ursula M. Munoz-Najar, Jessie C. Jeyapalan, Judith Campisi
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185-214
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Stuart K. Kim
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215-235
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Derrick J. Rossi, Norman E. Sharpless
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237-265
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Linda Partridge, John Tower
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267-308
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Vilhelm A. Bohr, David M. Wilson, Iii, Nadja C. De Souza-pinto, Ingrid van der Pluijm, J.H. Hoeijmakers
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309-346
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John J. Kopchick, Andrzej Bartke, Darlene E. Berryman
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347-369
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Philip C. Wong, Donald L. Price, Lars Bertram, Ronald E. Tanzi
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371-407
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Richard Weindruch, Ricki J. Colman, Viviana Pérez, Arlan G. Richardson
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409-425
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Gordon J. Lithgow, Richard A. Miller
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427-481
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Su-Ju Lin, David Sinclair
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483-516
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Thomas T. Perls, Paola Sebastiani
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517-544
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Pere Puigserver, C. Ronald Kahn
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545-574
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Jerry W. Shay, Woodring E. Wright
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575-597
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599-610
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