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This book presents a thorough analysis of the molecular events that govern DNA replication in eukaryotic cells. The association between genome replication and cell proliferation, disease pathogenesis, and the development of targeted therapeutics is also addressed. At least 160 proteins are involved in replicating the human genome, and at least 40 diseases are caused by aberrant DNA replication, 35 by mutations in genes required for DNA replication or repair, 7 by mutations generated during mitochondrial DNA replication, and more than 40 by DNA viruses. Consequently, a growing number of therapeutic drugs are targeted to DNA replication proteins. This authoritative volume provides a rich source of information for researchers, physicians, and teachers, and will stimulate thinking about the relevance of DNA replication to human disease.
Table of Contents
Articles
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Melvin L. Depamphilis
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i-xvii
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Thomas J. Kelly, Bruce Stillman
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1-29
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Mirit I. Aladjem, Arturo Falaschi, David Kowalski
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31-61
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Umasundari Sivaprasad, Anindya Dutta, Stephen P. Bell
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63-88
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Johannes C. Walter, Hiroyuki Araki
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89-104
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Peter M.J. Burgers, Yeon-Soo Seo
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105-120
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Paul D. Kaufman, Geneviève Almouzni
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121-140
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Robert A. Rollins, Marc Damelin, Timothy H. Bestor
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141-153
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Deepak Bastia, Bidyut K. Mohanty
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155-174
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David M. Gilbert, Susan M. Gasser
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175-196
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Anne D. Donaldson, Carl L. Schildkraut
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197-215
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Damien Grégoire, Marcel Méchali
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217-231
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Brian R. Calvi
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233-255
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Crisanto Gutierrez
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257-271
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Stephen D. Bell
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273-293
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Etienne Schwob, Karim Labib
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295-311
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Melvin L. Depamphilis, J. Julian Blow
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313-334
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Marco Foiani, Sanjay Kumar, Joel A. Huberman
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335-356
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Jean Gautier, Jiri Bartek
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357-376
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Errol C. Friedberg
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377-390
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Polina V. Shcherbakova, Thomas A. Kunkel
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391-409
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Toshiki Tsurimoto
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411-434
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Ashwini S. Kamath-Loeb, Lawrence A. Loeb, Michael Fry
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435-460
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John D. Cleary, Christopher E. Pearson, Albert R. La Spada
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461-480
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William C. Burhans, Antony M. Carr, Geoffrey M. Wahl
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481-500
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Nicholas Coleman, Anthony D. Mills, Ronald A. Laskey
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501-518
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Yves Pommier, Robert B. Diasio
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519-546
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David A. Clayton, Nils-Göran Larsson
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547-560
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David C.F. Sealey, Lea Harrington, Virginia A. Zakian
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561-591
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Susan F. Cotmore, Peter Tattersall
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593-608
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Louise T. Chow, Thomas R. Broker
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609-625
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Ellen Fanning, James M. Pipas
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627-644
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Peter C. van der Vliet, Rob C. Hoeben
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645-661
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Sandra K. Weller, Donald M. Coen
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663-686
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Wolfgang Hammerschmidt, Bill Sugden
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687-705
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Bernard Moss, Frank De Silva
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707-727
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Christoph Seeger, William S. Mason
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729-744
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Mirit I. Aladjem, Kurt W. Kohn
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745-750
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Lakshminarayan M. Iyer, L. Aravind
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751-757
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759-795
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797-814
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