
The second edition of Telomeres is an up-to-date survey of the exciting field of telomere biology. Telomeres-specialized structures found at the ends of chromosomes-are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and senescence, and how changes in these structures contribute to cancer and other diseases.
REVIEW OF THE FIRST EDITION
"Telomeres provides an excellent, easy-to-read introduction... . Moreover, since the book contains a wealth of information on all aspects of telomere biology and biochemistry, it should prove tremendously useful to even the most experienced telomere researcher."
-Science
Table of Contents
| Preface/Front Matter |
| Titia De Lange, Vicki Lundblad, Elizabeth Blackburn |
| Excerpt PDF (i-viii) |
|   |
| 1 A History of Telomere Biology |
| Elizabeth H. Blackburn |
| Excerpt PDF (1-19) |
|   |
| 2 The Telomerase Ribonucleoprotein Particle |
| Gaël Cristofari, Joachim Lingner |
| Excerpt PDF (21-47) |
|   |
| 3 Telomerase Biochemistry and Biogenesis |
| Jiunn-Liang Chen, Carol W. Greider |
| Excerpt PDF (49-79) |
|   |
| 4 Telomerase and Human Cancer |
| Jerry W. Shay, Woodring E. Wright |
| Excerpt PDF (81-108) |
|   |
| 5 Modeling Cancer and Aging in the Telomerase-deficient Mouse |
| Kwok-Kin Wong, Sandy Chang, Ronald A. Depinho |
| Excerpt PDF (109-138) |
|   |
| 6 Telomerase Deficiency and Human Disease |
| Inderjeet Dokal, Tom Vulliamy |
| Excerpt PDF (139-161) |
|   |
| 7 Telomerase-independent Maintenance of Mammalian Telomeres |
| Axel A. Neumann, Roger R. Reddel |
| Excerpt PDF (163-198) |
|   |
| 8 Telomerase-independent Telomere Maintenance in Yeast |
| Michael J. McEachern, James E. Haber |
| Excerpt PDF (199-224) |
|   |
| 9 Meiotic Telomeres |
| Harry Scherthan |
| Excerpt PDF (225-259) |
|   |
| 10 Telomere Position Effect: Silencing Near the End |
| Michelle A. Mondoux, Virginia A. Zakian |
| Excerpt PDF (261-316) |
|   |
| 11 The Structural Biology of Telomeres |
| Daniela Rhodes |
| Excerpt PDF (317-343) |
|   |
| 12 Budding Yeast Telomeres |
| Vicki Lundblad |
| Excerpt PDF (345-386) |
|   |
| 13 Mammalian Telomeres |
| Titia De Lange |
| Excerpt PDF (387-431) |
|   |
| 14 Drosophila Telomeres |
| Sergio Pimpinelli |
| Excerpt PDF (433-463) |
|   |
| 15 Ciliate Telomeres |
| Carolyn Price |
| Excerpt PDF (465-493) |
|   |
| 16 Fission Yeast Telomeres |
| Julia Promisel Cooper, Yasushi Hiraoka |
| Excerpt PDF (495-523) |
|   |
| 17 Plant Telomeres |
| Dorothy E. Shippen |
| Excerpt PDF (525-550) |
|   |
| Appendix: A Personal Account of the Discovery of Telomerase |
| Elizabeth H. Blackburn |
| Excerpt PDF (551-563) |
|   |
| Index |
| Excerpt PDF (565-576) |
|   |