The generation of new neurons in the adult mammalian brain is one of the most extraordinary examples of neuroplasticity. Bringing together leading researchers in the field of adult neurogenesis, this book provides a valuable overview of this emerging field and lays the groundwork for future studies. It includes discussions on neural stem cell biology, methods and models for studying adult neurogenesis, physiological and molecular processes and their control, related neurological diseases, and comparisons of neurogenesis in humans, birds, fish, and invertebrates. This volume will be of interest to researchers in neurobiology, as well as those with clinical interests, as it has implications for understanding depression, epilepsy, and other neurological and psychiatric disorders.
Table of Contents
| Preface/Front Matter |
| Fred H. Gage, Gerd Kempermann, Hongjun Song |
| Excerpt PDF (i-xii) |
| 1 Adult Neurogenesis: A Prologue |
| Fred H. Gage, Hongjun Song, Gerd Kempermann |
| Excerpt PDF (1-5) |
| 2 Numerology of Neurogenesis: Characterizing the Cell Cycle of Neurostem Cells |
| Richard S. Nowakowski, Nancy L. Hayes |
| Excerpt PDF (7-23) |
| 3 Detection and Phenotypic Characterization of Adult Neurogenesis |
| H. Georg Kuhn, Daniel A. Peterson |
| Excerpt PDF (25-47) |
| 4 Evolving Methods for the Labeling and Mutation of Postnatal Neuronal Precursor Cells: A Critical Review |
| Joshua J. Breunig, Pasko Rakic, Jeffrey D. Macklis |
| Excerpt PDF (49-80) |
| 5 The Use of Reporter Mouse Lines to Study Adult Neurogenesis |
| Grigori Enikolopov, Linda Overstreet-Wadiche |
| Excerpt PDF (81-100) |
| 6 Retrovirus-mediated Cell Labeling |
| Chunmei Zhao |
| Excerpt PDF (101-117) |
| 7 Neurospheres |
| Ilyas Singec, Alfredo Quiñones-Hinojosa |
| Excerpt PDF (119-134) |
| 8 Monolayer Cultures of Neural Stem/Progenitor Cells |
| Jasodhara Ray |
| Excerpt PDF (135-157) |
| 9 Neurogenesis in the Adult Hippocampus |
| Gerd Kempermann, Hongjun Song, Fred H. Gage |
| Excerpt PDF (159-174) |
| 10 Adult Subventricular Zone and Olfactory Bulb Neurogenesis |
| Daniel A. Lim, Yin-Cheng Huang, Arturo Alvarez-Buylla |
| Excerpt PDF (175-206) |
| 11 Neurogenic Niches in the Adult Mammalian Brain |
| Dengke K. Ma, Guo-Li Ming, Fred H. Gage, Hongjun Song |
| Excerpt PDF (207-225) |
| 12 Adult Neurogenesis: Similarities and Differences in Stem Cell Fate, Proliferation, Migration, and Differentiation in Distinct Forebrain Regions |
| D. Chichung Lie, Magdalena Götz |
| Excerpt PDF (227-265) |
| 13 Proneuronal Genes Drive Neurogenesis on the Road from Development to Adulthood |
| Elizabeth T. Buchen, Samuel J. Pleasure |
| Excerpt PDF (267-282) |
| 14 The Balance of Trophic Support and Cell Death in Adult Neurogenesis |
| H. Georg Kuhn |
| Excerpt PDF (283-298) |
| 15 Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus |
| Josef Bischofberger, Alejandro F. Schinder |
| Excerpt PDF (299-319) |
| 16 Genetics and Epigenetics in Adult Neurogenesis |
| Jenny Hsieh, Jay W. Schneider |
| Excerpt PDF (321-339) |
| 17 Activity Dependency and Aging in the Regulation of Adult Neurogenesis |
| Gerd Kempermann |
| Excerpt PDF (341-362) |
| 18 Regulation of Hippocampal Neurogenesis by Systemic Factors Including Stress, Glucocorticoids, Sleep, and Inflammation |
| Paul J. Lucassen, Charlotte A. Oomen, Anne-Marie van Dam, Boldizsár Czéh |
| Excerpt PDF (363-395) |
| 19 Regulation of Adult Neurogenesis by Neurotransmitters |
| Mi-Hyeon Jang, Hongjun Song, Guo-Li Ming |
| Excerpt PDF (397-423) |
| 20 Adult Neurogenesis in the Olfactory Bulb |
| Pierre-Marie Lledo |
| Excerpt PDF (425-443) |
| 21 Neurogenesis and Hippocampal Memory System |
| D. Nora Abrous, J. Martin Wojtowicz |
| Excerpt PDF (445-461) |
| 22 Computational Modeling of Adult Neurogenesis |
| James B. Aimone, Laurenz Wiskott |
| Excerpt PDF (463-481) |
| 23 Hippocampal Neurogenesis: Depression and Antidepressant Responses |
| Amar Sahay, Rene Hen, Ronald S. Duman |
| Excerpt PDF (483-501) |
| 24 Adult Neurogenesis in Neurodegenerative Diseases |
| Patrik Brundin, Jürgen Winkler, Eliezer Masliah |
| Excerpt PDF (503-533) |
| 25 Epilepsy and Adult Neurogenesis |
| Sebastian Jessberger, Jack M. Parent |
| Excerpt PDF (535-547) |
| 26 Neurogenesis following Stroke Affecting the Adult Brain |
| Olle Lindvall, Zaal Kokaia |
| Excerpt PDF (549-570) |
| 27 Adult Neurogenesis in Teleost Fish |
| Günther K.H. Zupanc |
| Excerpt PDF (571-592) |
| 28 Neurogenesis in the Adult Songbird: A Model for Inducible Striatal Neuronal Addition |
| Steve A. Goldman |
| Excerpt PDF (593-617) |
| 29 Adult Human Neurogenesis: A Response to Cell Loss and New Circuitry Requirements? |
| Maurice A. Curtis, Peter S. Eriksson, Richard L.M. Faull |
| Excerpt PDF (619-693) |
| 30 Adult Hippocampal Neurogenesis in Natural Populations of Mammals |
| Irmgard Amrein, Hans-Peter Lipp, Rudy Boonstra, J. Martin Wojtowicz |
| Excerpt PDF (645-659) |
| Index |
| Excerpt PDF (661-673) |