
How is the growth of a cell regulated? And how is that growth coordinated as the cell progresses through the division cycle? These are important questions in biology. If the signaling pathways that control growth go awry, the cells produced are too large or too small, leading to developmental abnormalities and errors and contributing to a variety of pathological conditions that include cancer, diabetes, and inflammation.
Fundamentally important and clinically relevant, the topic receives the close attention it deserves in Cell Growth: Control of Cell Size. With contributions from internationally renowned experts, the book discusses cell growth in the context of both development and cell division. It focuses on individual molecules and mechanisms that control cell size and describes cell growth in specific tissues. This volume serves as a valuable reference for established scientists in the field, as well as a superb introduction for those with more general interests in animal and plant cell biology.
Table of Contents
| Preface/Front Matter |
| Michael N. Hall, Martin Raff, George Thomas |
| Excerpt PDF (i-xii) |
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| 1 How Metazoans Reach Their Full Size: The Natural History of Bigness |
| Patrick H. O’Farrell |
| Excerpt PDF (1-22) |
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| 2 Growth and Cell Cycle Control in Drosophila |
| Bruce A. Edgar, H. Frederik Nijhout |
| Excerpt PDF (23-83) |
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| 3 Coordination of Cell Growth and Cell-cycle Progression in Proliferating Mammalian Cells |
| Ian Conlon, Alison Lloyd, Martin Raff |
| Excerpt PDF (85-99) |
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| 4 Coordination of Cell Growth and Cell Division |
| Emmett Vance Schmidt |
| Excerpt PDF (101-137) |
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| 5 TOR Signaling in Yeast: Temporal and Spatial Control of Cell Growth |
| Robbie Loewith, Michael N. Hall |
| Excerpt PDF (139-165) |
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| 6 Growth Regulation by Insulin and TOR Signaling in Drosophila |
| Sally J. Leevers, Ernst Hafen |
| Excerpt PDF (167-192) |
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| 7 Growth Control through the mTOR Network |
| David A. Guertin, Do-Hyung Kim, David M. Sabatini |
| Excerpt PDF (193-234) |
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| 8 IGF-I Receptor Signaling in Cell Growth and Proliferation |
| Renato Baserga |
| Excerpt PDF (235-263) |
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| 9 S6K Integrates Nutrient and Mitogen Signals to Control Cell Growth |
| Jacques Montagne, George Thomas |
| Excerpt PDF (265-298) |
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| 10 Translation Initiation and Cell Growth Control |
| Emmanuel Petroulakis, Nahum Sonenberg |
| Excerpt PDF (299-328) |
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| 11 Forging the Factory: Ribosome Synthesis and Growth Control in Budding Yeast |
| Paul Jorgensen, Mike Tyers, Jonathan R. Warner |
| Excerpt PDF (329-370) |
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| 12 Control of rRNA and tRNA Production Is Closely Tied to Cell Growth |
| Robert J. White |
| Excerpt PDF (371-412) |
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| 13 Autophagy: Reversing Cell Growth |
| Yoshinori Ohsumi |
| Excerpt PDF (413-429) |
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| 14 Synaptic Growth, Synaptic Maintenance, and the Persistence of Long-term Memory Storage |
| Craig H. Bailey, Robert D. Hawkins, Eric R. Kandel |
| Excerpt PDF (431-472) |
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| 15 Control of Synaptic Function by Local Protein Synthesis and Degradation |
| W. Bryan Smith, Baris Bingol, Gentry N. Patrick, Erin M. Schuman |
| Excerpt PDF (473-507) |
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| 16 Lymphocyte Growth |
| Daniel E. Bauer, Craig B. Thompson |
| Excerpt PDF (509-527) |
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| 17 Modulating Skeletal Muscle Hypertrophy and Atrophy: Signaling Pathways and Therapeutic Targets |
| David J. Glass, George D. Yancopoulos |
| Excerpt PDF (529-548) |
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| 18 Mechanisms Controlling Heart Growth in Mammals |
| Julie R. McMullen, Seigo Izumo |
| Excerpt PDF (549-603) |
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| 19 Regulation of Cell Growth in the Endocrine Pancreas |
| Kristin Roovers, Morris J. Birnbaum |
| Excerpt PDF (605-623) |
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| 20 Plant Cell Growth |
| Benoît Menand, Christophe Robaglia |
| Excerpt PDF (625-637) |
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| Subject Index |
| Excerpt PDF (639-652) |
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