
The editors are to be congratulated on assembling a high-powered collection of expert contributors to produce this large monograph, and, if you are seeking a snapshot of all the major topics of importance in the field of protein synthesis (particularly in eukaryotes) at the beginning of the 21st century, Translational Control of Gene Expression is the place to look... . I strongly recommend this publication as an authoritative source book, both for students entering the field and established practitioners alike, and it should find its way onto many laboratory benches and library shelves.
-Trends in Genetics
This book is the most complete and up-to-date review of translational control mechanisms. It is a must for students entering the field, and it will constitute for many years a major reference guide for an investigator who is seriously interested in the full picture of gene expression.
-Journal of Cell Science
Whether you are an advanced student or an experienced researcher, if you need to bring yourself up to speed on the translational control of gene expression, then this is the book for you. In 36 chapters almost every aspect of translational control, including the mechanisms of initiation, elongation and termination, control during development, control in response to extracellular stimuli and control during virus infection or cancer are dealt with. As you would expect from a Cold Spring Harbor Monograph, the volume is comprehensive, scholarly and as 'up-to-date' as this type of multi-author volume can hope to be... . I can recommend this volume to individual specialists and institutional libraries, both of which will get a lot of good value for their money.
-Microbiology Today
Table of Contents
| Preface/Front Matter |
| N. Sonenberg, J.W.B. Hershey, M.B. Mathews |
| Excerpt PDF (i-x) |
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| 1 Origins and Principles of Translational Control |
| Michael B. Mathews, Nahum Sonenberg, John W.B. Hershey |
| Excerpt PDF (1-31) |
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| 2 The Pathway and Mechanism of Initiation of Protein Synthesis |
| John W. B. Hershey, William C. Merrick |
| Excerpt PDF (33-88) |
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| 3 The Protein Biosynthesis, Elongation Cycle |
| William C. Merrick, Jens Nyborg |
| Excerpt PDF (89-125) |
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| 4 A Comparative View of Initiation Site Selection Mechanisms |
| Richard J. Jackson |
| Excerpt PDF (127-183) |
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| 5 Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes |
| Alan G. Hinnebusch |
| Excerpt PDF (185-243) |
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| 6 Regulation of Ribosomal Recruitment in Eukaryotes |
| Brian Raught, Anne-Claude Gingras, Nahum Sonenberg |
| Excerpt PDF (245-293) |
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| 7 Translational Control of Developmental Decisions |
| Marvin Wickens, Elizabeth B. Goodwin, Judith Kimble, Sidney Strickland, Matthias W. Hentze |
| Excerpt PDF (295-370) |
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| 8 Viral Translational Strategies and Host Defense Mechanisms |
| Tsafi Pe’ery, Michael B. Mathews |
| Excerpt PDF (371-424) |
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| 9 Ribosomal Subunit Joining |
| Tatyana V. Pestova, Christopher U.T. Hellen, Thomas E. Dever |
| Excerpt PDF (425-445) |
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| 10 Physical and Functional Interactions between the mRNA Cap Structure and the Poly(A) Tail |
| Alan Sachs |
| Excerpt PDF (447-465) |
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| 11 Translation Termination: It’s Not the End of the Story |
| Ellen M. Welch, Weirong Wang, Stuart W. Peltz |
| Excerpt PDF (467-485) |
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| 12 Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae |
| Thomas F. Donahue |
| Excerpt PDF (487-502) |
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| 13 The Double-stranded RNA-activated Protein Kinase PKR |
| Randal J. Kaufman |
| Excerpt PDF (503-527) |
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| 14 Heme-regulated eIF2α Kinase |
| Jane-Jane Chen |
| Excerpt PDF (529-546) |
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| 15 PERK and Translational Control by Stress in the Endoplasmic Reticulum |
| David Ron, Heather P. Harding |
| Excerpt PDF (547-560) |
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| 16 Regulation of Translation Initiation in Mammalian Cells by Amino Acids |
| Scot R. Kimball, Leonard S. Jefferson |
| Excerpt PDF (561-579) |
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| 17 Translational Control during Heat Shock |
| Robert J. Schneider |
| Excerpt PDF (581-593) |
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| 18 Translational Control by Upstream Open Reading Frames |
| Adam P. Geballe, Matthew S. Sachs |
| Excerpt PDF (595-614) |
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| 19 Cellular Internal Ribosome Entry Site Elements and the Use of cDNA Microarrays in Their Investigation |
| Mark S. Carter, Kenneth M. Kuhn, Peter Sarnow |
| Excerpt PDF (615-635) |
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| 20 Translational Control and Cancer |
| John W. B. Hershey, Suzanne Miyamoto |
| Excerpt PDF (637-654) |
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| 21 Translational Control of Ferritin Synthesis |
| Tracey A. Rouault, Joe B. Harford |
| Excerpt PDF (655-670) |
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| 22 Translational Control of TOP mRNAs |
| Oded Meyuhas, Eran Hornstein |
| Excerpt PDF (671-693) |
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| 23 S6 Phosphorylation and Signal Transduction |
| Stefano Fumagalli, George Thomas |
| Excerpt PDF (695-717) |
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| 24 Control of the Elongation Phase of Protein Synthesis |
| Christopher Proud |
| Excerpt PDF (719-739) |
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| 25 Programmed Translational Frameshifting, Hopping, and Readthrough of Termination Codons |
| Philip J. Farabaugh, Qiang Qian, Guillaume Stahl |
| Excerpt PDF (741-761) |
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| 26 Recoding UGA as Selenocysteine |
| Marla J. Berry |
| Excerpt PDF (763-783) |
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| 27 Influence of Polyadenylation-induced Translation on Metazoan Development and Neuronal Synaptic Function |
| Joel D. Richter |
| Excerpt PDF (785-805) |
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| 28 Interaction of mRNA Translation and mRNA Degradation in Saccharomyces cerevisiae |
| David C. Schwartz, Roy Parker |
| Excerpt PDF (807-825) |
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| 29 Destabilization of Nonsense-containing Transcripts in Saccharomyces cerevisiae |
| Allan Jacobson, Stuart W. Peltz |
| Excerpt PDF (827-847) |
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| 30 Nonsense-mediated RNA Decay in Mammalian Cells: A Splicing-dependent Means to Down-regulate the Levels of mRNAs That Prematurely Terminate Translation |
| Lynne E. Maquat |
| Excerpt PDF (849-868) |
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| 31 Translation Initiation on Picornavirus RNA |
| Graham J. Belsham, Richard J. Jackson |
| Excerpt PDF (869-900) |
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| 32 Adenovirus Inhibition of Cellular Protein Synthesis and Preferential Translation of Viral mRNAs |
| Robert J. Schneider |
| Excerpt PDF (901-914) |
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| 33 Reovirus Translational Control |
| Aaron J. Shatkin |
| Excerpt PDF (915-932) |
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| 34 Translational Reprogramming during Influenza Virus Infection |
| Seng-Lai Tan, Michael G. Katze, Michael J. Gale, Jr. |
| Excerpt PDF (933-950) |
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| 35 Translational Control in Poxvirus-infected Cells |
| Bertram L. Jacobs |
| Excerpt PDF (951-971) |
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| 36 Nontranslational Functions of Components of the Translational Apparatus |
| Terri Goss Kinzy, Emanuel Goldman |
| Excerpt PDF (973-997) |
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| Index |
| Excerpt PDF (999-1020) |
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