This definitive account of prion biology and disease was assembled to provide investigators with reliable reference material, young scientists with encouragement to explore the field, and educators with information on a topic that has captured the imagination of students at every level. The most authoritative and up-to-date source of knowledge yet published on this unique form of pathogen, the book has been written by Stanley Prusiner, winner of a 1997 Nobel Prize for his discovery of prions, and a group of internationally recognized experts on prions' biology and pathogenic effects.
Table of Contents
| Preface/Front Matter |
| Stanley B. Prusiner |
| Excerpt PDF (i-xiii) |
| 1 An Introduction to Prion Biology and Diseases |
| Stanley B. Prusiner |
| Excerpt PDF (1-66) |
| 2 Development of the Prion Concept |
| Stanley B. Prusiner |
| Excerpt PDF (67-112) |
| 3 Bioassays of Prions |
| Stanley B. Prusiner, Patrick Tremblay, Jiri Safar, Marilyn Torchia, Stephen J. Dearmond |
| Excerpt PDF (113-145) |
| 4 Transmission and Replication of Prions |
| Stanley B. Prusiner, Michael R. Scott, Stephen J. Dearmond, George Carlson |
| Excerpt PDF (147-190) |
| 5 Structural Studies of Prion Proteins |
| Fred E. Cohen, Stanley B. Prusiner |
| Excerpt PDF (191-228) |
| 6 Prions of Fungi: [URE3], [PSI], and [Het-s] Discovered as Heritable Traits |
| Reed B. Wickner, Yury O. Chernoff |
| Excerpt PDF (229-272) |
| 7 Knockouts, Transgenics, and Transplants in Prion Research |
| C. Weissmann, A.J. Raeber, D. Shmerling, A. Aguzzi, J.C. Manson |
| Excerpt PDF (273-305) |
| 8 Transgenetic Investigations of the Species Barrier and Prion Strains |
| Michael Scott, Stephen J. Dearmond, Stanley B. Prusiner, Rosalind M. Ridley, Harry F. Baker |
| Excerpt PDF (307-347) |
| 9 Cell Biology of Prions |
| Stanley B. Prusiner, Peter Peters, Kiyotoshi Kaneko, Albert Taraboulos, Vishwanath Lingappa, Fred E. Cohen, Stephen J. Dearmond |
| Excerpt PDF (349-391) |
| 10 Scrapie, Chronic Wasting Disease, and Transmissible Mink Encephalopathy |
| Jean-Louis Laplanche, Nora Hunter, Morikazu Shinagawa, Elizabeth Williams |
| Excerpt PDF (393-429) |
| 11 Bovine Spongiform Encephalopathy and Related Diseases |
| Neal Nathanson, John Wilesmith, Gerald A. Wells, Christian Griot |
| Excerpt PDF (431-463) |
| 12 Infectious and Sporadic Prion Diseases |
| R.G. Will, M.P. Alpers, D. Dormont, L.B. Schonberger, J. Tateishi |
| Excerpt PDF (465-507) |
| 13 Inherited Prion Diseases |
| Pierluigi Gambetti, Robert B. Petersen, Piero Parchi, Shu G. Chen, Sabina Capellari, Lev Goldfarb, Ruth Gabizon, Pasquale Montagna, Elio Lugaresi, Pedro Piccardo, Bernardino Ghetti |
| Excerpt PDF (509-583) |
| 14 Neuropathology of Prion Diseases |
| Stephen J. Dearmond, James W. Ironside |
| Excerpt PDF (585-652) |
| 15 Some Strategies and Methods for the Study of Prions |
| Stanley B. Prusiner, Kiyotoshi Kaneko, Hana Serban, Fred E. Cohen, Jiri Safar, Detlev Riesner |
| Excerpt PDF (653-715) |
| 16 Antibodies as Tools to Probe Prion Protein Biology |
| R. Anthony Williamson, Dennis R. Burton, David Peretz, Zoltan Kanyo |
| Excerpt PDF (717-741) |
| 17 Biosafety Issues in Prion Diseases |
| Henry Baron, Jiri Safar, Darlene Groth, Stephen J. Dearmond, Stanley B. Prusiner |
| Excerpt PDF (743-777) |
| Index |
| Excerpt PDF (779-794) |