The heat shock proteins and molecular chaperones form large gene families and are active in every cellular compartment, regulating protein folding, translocation and complex assembly. A sequel to the 1990 volume, Stress Proteins in Biology and Medicine, this monograph updates progress and introduces new fields of investigation. Particular emphasis is given to the biochemical properties of hs proteins and chaperones in protein biogenesis, the role of hs proteins in thermotolerance and cytoprotection, transcriptional regulation of hs genes, and the function of the hs response in immunology and disease.
This is a thoughtful and comprehensive account of a field of investigation that has been developing at a breathtaking pace. The book is a vital resource for investigators in cell biology, protein biochemistry and molecular genetics, and those with interests in immunity, ischemic disease and aging.
Table of Contents
| Preface/Front Matter |
| Excerpt PDF (i-vii) |
| 1 Progress and Perspectives on the Biology of Heat Shock Proteins and Molecular Chaperones |
| Richard I. Morimoto, Alfred Tissières, Costa Georgopoulos |
| Excerpt PDF (1-30) |
| 2 Cytosolic hsp70s of Saccharomyces cerevisiae: Roles in Protein Synthesis, Protein Translocation, Proteolysis, and Regulation |
| Elizabeth A. Craig, Bonnie K. Baxter, Jörg Becker, John Halladay, Thomas Ziegelhoffer |
| Excerpt PDF (31-52) |
| 3 Chaperoning Mitochondrial Biogenesis |
| Thomas Langer, Walter Neupert |
| Excerpt PDF (53-83) |
| 4 Heat Shock Cognate Proteins and Polypeptide Translocation Across the Endoplasmic Reticulum Membrane |
| Jeffrey L. Brodsky, Randy Schekman |
| Excerpt PDF (85-109) |
| 5 Structure, Function, and Regulation of the Endoplasmic Reticulum Chaperone, BiP |
| Mary-Jane Gething, Sylvie Blond-Elguindi, Kazutoshi Mori, Joseph F. Sambrook |
| Excerpt PDF (111-135) |
| 6 Heat Shock 70-kD Proteins and Lysosomal Proteolysis |
| J. Fred Dice, Fernando Agarraberes, Melissa Kirven-Brooks, Laura J. Terlecky, Stanley R. Terlecky |
| Excerpt PDF (137-151) |
| 7 Stress-70 Proteins and Their Interaction with Nucleotides |
| David B. McKay, Sigurd M. Wilbanks, Kevin M. Flaherty, Jeung-Hoi Ha, Melanie C. O’Brien, Lauren L. Shirvanee |
| Excerpt PDF (153-177) |
| 8 Interactions of Vertebrate hsc70 and hsp70 with Unfolded Proteins and Peptides |
| Lawrence E. Hightower, Seth E. Sadis, Ivone M. Takenaka |
| Excerpt PDF (179-207) |
| 9 Properties of the Heat Shock Proteins of Escherichia coli and the Autoregulation of the Heat Shock Response |
| Costa Georgopoulos, Krzysztof Liberek, Maciej Zylicz, Debbie Ang |
| Excerpt PDF (209-249) |
| 10 Molecular Chaperone Functions of hsp70 and hsp60 in Protein Folding |
| Judith Frydman, Franz-Ulrich Hartl |
| Excerpt PDF (251-283) |
| 11 The Basis of Recognition of Nonnative Structure by the Chaperone SecB |
| Linda L. Randall, Traci B. Topping, Simon J.S. Hardy |
| Excerpt PDF (285-298) |
| 12 The Structure, Function, and Genetics of the Chaperonin Containing TCP-1 (CCT) in Eukaryotic Cytosol |
| Keith R. Willison, Hiroshi Kubota |
| Excerpt PDF (299-312) |
| 13 Modulation of Steroid Receptor Signal Transduction by Heat Shock Proteins |
| Sean P. Bohen, Keith R. Yamamoto |
| Excerpt PDF (313-334) |
| 14 Expression and Function of the Low-molecular-weight Heat Shock Proteins |
| Andre-Patrick Arrigo, Jacques Landry |
| Excerpt PDF (335-373) |
| 15 Structure and Regulation of Heat Shock Gene Promoters |
| Mary Fernandes, Thomas O’Brien, John T. Lis |
| Excerpt PDF (375-393) |
| 16 Structure and Regulation of Heat Shock Transcription Factor |
| Carl Wu, Joachim Clos, Gisele Giorgi, Raymond I. Haroun, Soon-Jong Kim, Sridhar K. Rabindran, J. Timothy Westwood, Jan Wisniewski, Gloria Yim |
| Excerpt PDF (395-416) |
| 17 Regulation of Heat Shock Gene Transcription by a Family of Heat Shock Factors |
| Richard I. Morimoto, Donald A. Jurivich, Paul E. Kroeger, Sameer K. Mathur, Shawn P. Murphy, Akira Nakai, Kevin Sarge, Klara Abravaya, Lea T. Sistonen |
| Excerpt PDF (417-455) |
| 18 Heat Shock Proteins and Stress Tolerance |
| Dawn A. Parsell, Susan Lindquist |
| Excerpt PDF (457-494) |
| 19 Heat Shock Proteins as Antigens in Immunity against Infection and Self |
| Stefan H.E. Kaufmann, Bernd Schoel |
| Excerpt PDF (495-531) |
| 20 Expression and Function of Stress Proteins in the Ischemic Heart |
| Ivor J. Benjamin, R. Sanders Williams |
| Excerpt PDF (533-552) |
| 21 Postischemic Stress Response in Brain |
| Thaddeus S. Nowak, Jr., Hiroshi Abe |
| Excerpt PDF (553-575) |
| 22 Heat Shock Protein Gene Expression in Response to Physiologic Stress and Aging |
| Nikki J. Holbrook, Robert Udelsman |
| Excerpt PDF (577-593) |
| Index |
| Excerpt PDF (595-610) |