Volume II: The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression (1992, Volume 21B)

Cover Page

In all eukaryotic cells, each fundamental process-cycle progression and its control, protein secretion and targeting, transcription and its regulation, mRNA processing, and DNA replication-accomplished by essentially identical cellular machinery composed of essentially identical protein components. This conservation of function has catapulted the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe from parochial backwaters to the forefront of experimental molecular biology: What is true for a yeast is true for an elephant, and in experiments you can get the answer a lot faster from a yeast.

This burgeoning appreciation of yeasts as model systems for the study of fundamental cellular processes has highlighted the need for an update of the seminal 1981 monograph The Molecular Biology of the Yeast Saccharomyces. This need is now met by the publication of a three-volume series to serve as the authoritative sequel. The first volume focuses on the genome organization of the yeast Saccharomyces as well as protein translation and its regulation and energy metabolism. Subsequent volumes emphasize such topics as the cell cycle, secretion, and transcription. Together, these volumes provide a comprehensive survey of the molecular and cellular biology of Saccharomyces and Schizosaccharomyces, serving not only as a current summary of every significant area of investigation, but also as a thorough reference source. These volumes are required reading for everyone in the field and anyone curious about the state of the art of molecular and cellular biology.

The Molecular and Cellular Biology of the Yeast Saccharomyces (Monograph 21):

  • Volume 1 (Monograph 21A): Genome Dynamics, Protein Synthesis, and Energetics
  • Volume 2 (Monograph 21B): Gene Expression
  • Volume 3 (Monograph 21C): Cell Cycle and Cell Biology

Earlier Edition - The Molecular Biology of the Yeast Saccharomyces: (Monograph 11):

  • Volume 1 (Monograph 11A): Life Cycle and Inheritance (out of print)
  • Volume 2 (Monograph 11B): Metabolism and Gene Expression

Table of Contents

Preface/Front Matter
Elizabeth W. Jones, John R. Pringle, James R. Broach
Excerpt       PDF     (i-viii)
1 Yeast Nuclear RNA Polymerases
Pierre Thuriaux, André Sentenac
Excerpt       PDF     (1-48)
2 Messenger RNA Transcription and Its Control in Saccharomyces cerevisiae
Leonard Guarente
Excerpt       PDF     (49-98)
3 Processing of Yeast Cytoplasmic and Mitochondrial Precusor tRNAs
Anita K. Hopper, Nancy C. Martin
Excerpt       PDF     (99-141)
4 Yeast Pre-mRNA Splicing
Brian C. Rymond, Michael Rosbash
Excerpt       PDF     (143-192)
5 Regulation of Carbon and Phosphate Utilization
Mark Johnston, Marian Carlson
Excerpt       PDF     (193-281)
6 Regulation of Nitrogen Utilization
Boris Magasanik
Excerpt       PDF     (283-317)
7 General and Pathway-specific Regulatory Mechanisms Controlling the Synthesis of Amino Acid Biosynthetic Enzymes in Saccharomyces cerevisiae
Alan G. Hinnebusch
Excerpt       PDF     (319-414)
8 Regulation and Compartmentalization of Lipid Synthesis in Yeast
Fritz Paltauf, Sepp D. Kohlwein, Susan A. Henry
Excerpt       PDF     (415-500)
9 The Heat-shock Response of Saccharomyces cerevisiae
Elizabeth A. Craig
Excerpt       PDF     (501-537)
10 The Yeast Ubiquitin System
Daniel Finley
Excerpt       PDF     (539-581)
11 Mating-type Determination and Mating-type Interconversion in Saccharomyces cerevisiae
Ira Herskowitz, Jasper Rine, Jeffrey Strathern
Excerpt       PDF     (583-656)
12 Pheromone Response and Signal Transduction during the Mating Process of Saccharomyces cerevisiae
George F. Sprague, Jr., Jeremy W. Thorner
Excerpt       PDF     (657-744)
13 Molecular Genetics of Fission Yeast Cell Type: Mating Type and Mating-type Interconversion
Amar J.S. Klar
Excerpt       PDF     (745-777)
Excerpt       PDF     (779-810)