Volume I: The Molecular and Cellular Biology of the Yeast Saccharomyces: Genome Dynamics, Protein Synthesis, and Energetics (1991, Volume 21A)

Cover Page

In all eukaryotic cells, each fundamental process-cycle progression and its control, protein secretion and targeting, transcription and its regulation, mRNA processing, and DNA replication-accomplished by essentially identical cellular machinery composed of essentially identical protein components. This conservation of function has catapulted the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe from parochial backwaters to the forefront of experimental molecular biology: What is true for a yeast is true for an elephant, and in experiments you can get the answer a lot faster from a yeast.

This burgeoning appreciation of yeasts as model systems for the study of fundamental cellular processes has highlighted the need for an update of the seminal 1981 monograph The Molecular Biology of the Yeast Saccharomyces. This need is now met by the publication of a three-volume series to serve as the authoritative sequel. The first volume focuses on the genome organization of the yeast Saccharomyces as well as protein translation and its regulation and energy metabolism. Subsequent volumes emphasize such topics as the cell cycle, secretion, and transcription. Together, these volumes provide a comprehensive survey of the molecular and cellular biology of Saccharomyces and Schizosaccharomyces, serving not only as a current summary of every significant area of investigation, but also as a thorough reference source. These volumes are required reading for everyone in the field and anyone curious about the state of the art of molecular and cellular biology.

The Molecular and Cellular Biology of the Yeast Saccharomyces (Monograph 21):

  • Volume 1 (Monograph 21A): Genome Dynamics, Protein Synthesis, and Energetics
  • Volume 2 (Monograph 21B): Gene Expression
  • Volume 3 (Monograph 21C): Cell Cycle and Cell Biology

Earlier Edition - The Molecular Biology of the Yeast Saccharomyces: (Monograph 11):

  • Volume 1 (Monograph 11A): Life Cycle and Inheritance (out of print)
  • Volume 2 (Monograph 11B): Metabolism and Gene Expression

Table of Contents

Preface/Front Matter
J.R. Broach, J.R. Pringle, E.W. Jones
Excerpt       PDF     (i-ix)
1 Genome Structure and Organization in Saccharomyces cerevisiae
Maynard V. Olson
Excerpt       PDF     (1-39)
2 Chromosomal DNA Replication
Judith L. Campbell, Carol S. Newlon
Excerpt       PDF     (41-146)
3 Cellular Responses to DNA Damage in Yeast
Errol C. Friedberg, Wolfram Siede, A. Jane Cooper
Excerpt       PDF     (147-192)
4 Yeast Transposable Elements
Jef D. Boeke, Suzanne B. Sandmeyer
Excerpt       PDF     (193-261)
5 Yeast RNA Virology The Killer Systems
Reed B. Wickner
Excerpt       PDF     (263-296)
6 Circular DNA Plasmids of Yeasts
James R. Broach, Fredric C. Volkert
Excerpt       PDF     (297-331)
7 Biogenesis of Yeast Mitochondria
Liza Pon, Gottfried Schatz
Excerpt       PDF     (333-406)
8 Recombination in Yeast
Thomas D. Petes, Robert E. Malone, Lorraine S. Symington
Excerpt       PDF     (407-521)
9 Transport across Yeast Vacuolar and Plasma Membranes
Ramon Serrano
Excerpt       PDF     (523-585)
10 The Ribosome and Its Synthesis
John L. Woolford, Jr., Jonathan R. Warner
Excerpt       PDF     (587-626)
11 Protein Synthesis and Translational Control in Saccharomyces cerevisiae
Alan G. Hinnebusch, Susan W. Liebman
Excerpt       PDF     (627-735)
APPENDIX Genetic and Physical Maps of Saccharomyces cerevisiae
Robert K. Mortimer, C. Rebecca Contopoulou, Jeff S. King
Excerpt       PDF     (737-812)
Subject Index
Excerpt       PDF     (813-826)