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8 Entry of Minor Group Human Rhinoviruses into the Cell
Abstract
The majority (91 serotypes) of the HRVs gain access to the cell via the intercellular adhesion molecule 1 (ICAM-1). How this protein manages the rapid delivery of the virus into the cell is not clear, since it is devoid of an internalization signal in its cytoplasmic carboxy-terminal region (Greve et al. 1989; Staunton et al. 1989; Tomassini et al. 1989). Only one serotype (HRV-87) attaches to a sialylated membrane protein of unknown function. However, the remainder of 10 serotypes, the minor receptor group, is internalized via membrane proteins which for a long time escaped identification. Whereas major group viruses exclusively bind to cells of human or primate origin, minor group viruses attach to cells of a large variety...
DOI: http://dx.doi.org/10.1101/0.129-140