APPENDIX I: Genetic Map of Saccharomyces cerevisiae

Abstract

The compilation of genetic mapping data that appeared in the companion volume of this series1 and in more detail as a complete review (Mortimer and Schild 1980) was completed in January 1980. That map described the locations of 317 genes on 17 chomosomes and 3 fragments. In the succeeding 2½ years there have been many changes in and additions to that map; because of this, we were asked to prepare an updated map for inclusion in this volume. Ninety-eight new genes have been located on the map, and these genes, their locations, and the sources of the new data are described in the accompanying list of mapped genes. The group of genes located on chromosome XVII of the 1980 map have been found not to define a separate chromosome but instead to be located on the left arm of chromosome XIV (Klapholz and Easton-Esposito 1982). A centromere-linked marker, KRB1, has been excluded from chromosomes I–XVI and now serves to identify a new chromosome XVII (Wickner et al. 1982a). Several linkages based only on mitotic crossing-over or trisomic analysis have been confirmed by tetrad analysis. Some sequence ambiguities have been cleared up and others have been introduced. Two genes (lys 10 and SAD1) that appeared on the 1980 map have been deleted, and the lengths of several intervals have been changed by the new data. The newly mapped genes have mostly fallen in already established intervals, although five chromosome arms have been extended by new linkages. The total genetic map...