The TGF-β Family (2008, Volume 50)

Cover Page

Transforming growth factor-b (TGF-b), identified nearly three decades ago, is a secreted polypeptide that functions in critical cell cycle processes, including cellular proliferation, differentiation, and development. It belongs to a large protein family that, in humans, contains 33 members, including activins, inhibins, bone morphogenetic proteins, growth and differentiation factors, and Müllerian inhibiting substance. This volume draws on the world's leading laboratories to comprehensively cover all aspects of the biology of TGF-b and related factors. In addition to providing historical and background information, it describes the cell biology and signaling pathways of TGF-b members in detail, including the roles of TGF-b factors in the development and physiology of humans and model organisms. The last few chapters are devoted to the role of TGF-b members in cancer and other diseases, as well as the possibilities for therapeutics based on knowledge of signaling pathways and macromolecular structures. It serves as a comprehensive reference work for both specialists and researchers less familiar with the field.

Table of Contents

Preface/Front Matter
R. Derynck, K. Miyazono
Excerpt       PDF     (i-xiv)
 
1 The Discovery of TGF-β: A Historical Perspective
Harold L. Moses, Anita B. Roberts
Excerpt       PDF     (1-28)
 
2 TGF-β and the TGF-β Family
Rik Derynck, Kohei Miyazono
Excerpt       PDF     (29-43)
 
3 TGF-β: A Multipotential Cytokine
Stephen H. Schilling, Anita B. Hjelmeland, Jeremy N. Rich, Xiao-Fan Wang
Excerpt       PDF     (45-77)
 
4 Activins and Inhibins
Ezra Wiater, Wylie Vale
Excerpt       PDF     (79-120)
 
5 The Bone Morphogenetic Proteins
Takenobu Katagiri, Tatsuo Suda, Kohei Miyazono
Excerpt       PDF     (121-149)
 
6 Signaling Receptors of the TGF-β Family
Jeffrey L. Wrana, Barish Ozdamar, Christine Le Roy, Hassina Benchabane
Excerpt       PDF     (151-177)
 
7 TGF-β Bioavailability: Latency, Targeting, and Activation
Branka Dabovic, Daniel B. Rifkin
Excerpt       PDF     (179-202)
 
8 Agonists and Antagonists of the TGF-β Family Ligands
Chenbei Chang
Excerpt       PDF     (203-257)
 
9 TGF-β Signaling from Receptors to Smads
Carl-Henrik Heldin
Excerpt       PDF     (259-285)
 
10 Transcriptional Control via Smads
Xia Lin, Ye-Guang Chen, Xin-Hua Feng
Excerpt       PDF     (287-332)
 
11 Growth Control by TGF-β: Mechanisms Controlling Cell Cycle Progression and Apoptosis
Peter M. Siegel, Joan Massagué
Excerpt       PDF     (333-362)
 
12 Regulation of TGF-β Family Signaling by Inhibitory Smads
Kohei Miyazono
Excerpt       PDF     (363-387)
 
13 Structural Basis for TGF-β Family Receptor Assembly and Signaling Specificity
Kai Lin, Senyon Choe
Excerpt       PDF     (389-417)
 
14 Non-Smad TGF-β Signaling Pathways
Ying E. Zhang
Excerpt       PDF     (419-437)
 
15 Regulation of the Smad Pathway by Signaling Cross-Talk
Kunxin Luo
Excerpt       PDF     (439-459)
 
16 TGF-β Family Signaling in Early Postimplantation Development of the Mouse
Shigeto Miura, Malcolm Whitman, Yuji Mishina
Excerpt       PDF     (461-491)
 
17 TGF-β Family Signaling in Drosophila
George Pyrowolakis, Britta Hartmann, Markus Affolter
Excerpt       PDF     (493-526)
 
18 TGF-β Family Signaling in the Nematode C. elegans
Garth I. Patterson, Richard W. Padgett
Excerpt       PDF     (527-545)
 
19 TGF-β Family Signaling in Xenopus and Zebrafish Embryos
Malcolm Whitman
Excerpt       PDF     (547-584)
 
20 TGF-β Family Signaling in Stem Cell Renewal and Differentiation
Tetsuro Watabe, Kohei Miyazono
Excerpt       PDF     (585-611)
 
21 TGF-β Family Signaling in Mesenchymal Differentiation
Rik Derynck, Ester Piek, Richard A. Schneider, Lisa Choy, Tamara Alliston
Excerpt       PDF     (613-665)
 
22 TGF-β Family Signaling in Skeletal Development, Maintenance, and Disease
Tamara Alliston, Ester Piek, Rik Derynck
Excerpt       PDF     (667-723)
 
23 TGF-β Family in Epithelial Development
Nina M. Muñoz, William M. Grady
Excerpt       PDF     (725-759)
 
24 The TGF-β Family in Endothelial Cell Differentiation and Cardiovascular Development and Function
Marie-José Goumans, Rita Carvalho, Christine Mummery, Peter Ten Dijke
Excerpt       PDF     (761-788)
 
25 TGF-β as a Regulator of Myeloid and Lymphoid Development and Function
John J. Letterio, Francis W. Ruscetti
Excerpt       PDF     (789-817)
 
26 The TGF-β Family in Neural and Neuronal Differentiation and Development
Jayshree Samanta, Michael A. Bonaguidi, John A. Kessler
Excerpt       PDF     (819-860)
 
27 The TGF-β Family in the Reproductive Tract
Stephanie A. Pangas, Martin M. Matzuk
Excerpt       PDF     (861-888)
 
28 TGF-β Signaling Pathway and Tumor Suppression
William M. Grady, Sanford D. Markowitz
Excerpt       PDF     (889-937)
 
29 TGF-β Signaling in Epithelial–Mesenchymal Transition and Invasion and Metastasis
Rosemary J. Akhurst
Excerpt       PDF     (939-964)
 
30 TGF-β and the Tumor Microenvironment
Brian Bierie, Harold L. Moses
Excerpt       PDF     (965-987)
 
31 TGF-β and Fibrosis
Erwin P. Böttinger
Excerpt       PDF     (989-1022)
 
32 Development of TGF-β-based Therapeutic Agents: Capitalizing on TGF-β’s Mechanisms of Action and Signal Transduction Pathways
Carlos L. Arteaga, John M. McPherson
Excerpt       PDF     (1023-1061)
 
33 BMP-based Therapeutics and the BMP Signaling Pathways
Gerard Bain, Anthony J. Celeste, John M. Wozney
Excerpt       PDF     (1063-1093)
 
Index
Excerpt       PDF     (1095-1114)