Reverse Transcriptase (1993, Volume 23)

Cover Page

Two decades after the discovery of its central role in retroviral transformation, reverse transcriptase still provokes a consuming interest in molecular biology. This book is the first comprehensive review of the enzyme's biology and it includes rare discussions of RT's functions outside the context of retroviruses. Also covered are the latest structural data on RT and a review of the antiviral activity of the enzyme's inhibitors. This monograph is a durable reference work for virologists and all molecular biologists whose work exploits RT's unique properties.

Table of Contents

Preface/Front Matter
Anna Marie Skalka, Stephen P. Goff
Excerpt       PDF     (i-ix)
1 The Treasure Under the Right Stone
David Baltimore
Excerpt       PDF     (1-3)
2 Mechanisms of Translational Suppression Used in the Biosynthesis of Reverse Transcriptase
Judith G. Levin, Dolph L. Hatfield, Stephen Oroszlan, Alan Rein
Excerpt       PDF     (5-31)
3 Regulation of Initiation of Reverse Transcription of Retroviruses
Jonathan Leis, Ashok Aiyar, David Cobrinik
Excerpt       PDF     (33-47)
4 Strong-stop Strand Transfer during Reverse Transcription
Alice Telesnitsky, Stephen P. Goff
Excerpt       PDF     (49-83)
5 The Fidelity of Retroviral Reverse Transcriptases
Katarzyna Bebenek, Thomas A. Kunkel
Excerpt       PDF     (85-102)
6 Roles of Ribonuclease H in Reverse Transcription
James J. Champoux
Excerpt       PDF     (103-117)
7 Strand Displacement Synthesis by Reverse Transcriptase
Lawrence R. Boone, Anna Marie Skalka
Excerpt       PDF     (119-133)
8 Genetic Analysis of Retroviral Reverse Transcriptase Structure and Function
Vinayaka R. Prasad
Excerpt       PDF     (135-162)
9 Human Immunodeficiency Virus Reverse Transcriptase
Stuart F.J. Le Grice
Excerpt       PDF     (163-191)
10 Endonuclease Activity Associated with Reverse Transcriptase of Avian Sarcoma-Leukosis Viruses
Anna Marie Skalka
Excerpt       PDF     (193-204)
11 Inhibitors of HIV Reverse Transcriptase as Antiviral Agents and Drug Resistance
Brendan A. Larder
Excerpt       PDF     (205-222)
12 The Structure of HIV-1 Reverse Transcriptase
Lori A. Kohlstaedt, Jimin Wang, Phoebe A. Rice, Jonathan M. Friedman, Thomas A. Steitz
Excerpt       PDF     (223-249)
13 Role of Reverse Transcriptase in Retroviral Recombination
Wei-shau Hu, Vinay K. Pathak, Howard M. Temin
Excerpt       PDF     (251-274)
14 Retrotransposon Reverse Transcription
Abram Gabriel, Jef D. Boeke
Excerpt       PDF     (275-328)
15 Reverse Transcription Pathway of the Hepatitis B Viruses
Daniel D. Loeb, Don Ganem
Excerpt       PDF     (329-355)
16 A Reverse Transcriptase for Cauliflower Mosaic Virus State of the Art, 1992
Jean-Marc Bonneville, Thomas Hohn
Excerpt       PDF     (357-390)
17 Bacterial Reverse Transcriptase
Sumiko Inouye, Masayori Inouye
Excerpt       PDF     (391-410)
18 Telomerases
Elizabeth H. Blackburn
Excerpt       PDF     (411-424)
19 Evolutionary History of Reverse Transcriptase
Marcella A. McClure
Excerpt       PDF     (425-444)
20 Reverse Transcription and Evolution
John M. Coffin
Excerpt       PDF     (445-479)
The First Ever Retrotriviacrossword
Excerpt       PDF     (481-484)
Excerpt       PDF     (485-492)